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Aciclovir is indicated for the management of viral infections caused by Herpes simplex virus (HSV type I & II) and Varicella zoster virus, including:
Treatment of herpes simplex infections of the skin and mucous membranes, such as primary and recurrent genital herpes and herpes labialis
Management of herpes zoster (shingles) and chickenpox
Prevention of herpes simplex infections in immunocompromised individuals
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ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
- ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Aciclovir is a synthetic purine nucleoside analogue with selective antiviral activity against HSV and Varicella-zoster virus. Its antiviral action depends on its conversion inside infected cells to Aciclovir triphosphate, the active metabolite.
The initial phosphorylation occurs via virus-encoded thymidine kinase, followed by further phosphorylation by host cellular enzymes. Aciclovir triphosphate inhibits viral DNA synthesis by competitively inhibiting viral DNA polymerase and terminating viral DNA chain elongation, thereby suppressing viral replication.
After oral administration, approximately 15–30% of the dose is absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 1.5 to 2 hours. Aciclovir is widely distributed throughout body tissues and fluids, including the brain, cerebrospinal fluid, lungs, liver, saliva, vaginal secretions, and herpetic vesicular fluid. The drug is primarily eliminated via the kidneys through glomerular filtration and tubular secretion.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Adverse Effects
- Skin rash
- Gastrointestinal disturbances
- Elevated liver enzymes and bilirubin
- Increased blood urea and creatinine
- Hematological changes
- Headache, fatigue, and neurological reactions
✔️ Dosage and Administration
Herpes Simplex – Initial Infection
Adults: 200 mg, 5 times daily for 5 days
Immunocompromised Patients
Adults: 400 mg, 5 times daily for 5 days
Duration may be extended if lesions persist
Dose may be increased to 800 mg, 5 times daily for genital herpes, if required
Children
Under 2 years: Half of the adult dose
Over 2 years: Adult dose
Prevention of Recurrent Herpes Simplex
Adults:
200 mg, 4 times daily or
400 mg, twice daily
Dose may be reduced to 200 mg, 2–3 times daily
Treatment should be reviewed and interrupted every 6–12 months
Prophylaxis in Immunocompromised Patients
Adults: 200–400 mg, 4 times daily
Children:
Under 2 years: Half of adult dose
Over 2 years: Adult dose
Treatment of Chickenpox (Varicella)
Adults and children >40 kg: 800 mg, 4 times daily for 5 days
Children <40 kg: 20 mg/kg per dose (maximum 800 mg), 4 times daily for 5 days
Children 1 month–2 years: 200 mg, 4 times daily
Children 2–5 years: 400 mg, 4 times daily
Children 6–12 years: 800 mg, 4 times daily
Treatment of Herpes Zoster (Shingles)
Adults: 800 mg, 5 times daily for 7 days
Initial Rectal (Proctitis) Herpes
Adults: 400 mg, 5 times daily for 10 days or until complete clinical resolution
Renal Impairment
Dose adjustment is recommended in patients with severe renal dysfunction, based on creatinine clearance.
✔️ Drug Interactions
Probenecid may reduce renal excretion of Aciclovir, leading to increased plasma levels and a higher risk of toxicity.
✔️ Contraindications
Aciclovir is contraindicated in patients with known hypersensitivity to Aciclovir or any of its components.
✔️ Pregnancy and Lactation
Pregnancy Category B
Aciclovir should be used during pregnancy only if the potential benefit outweighs the possible risk to the fetus
Caution is advised when administered to breastfeeding mothers
✔️ Precautions and Warnings
Use with caution in patients with renal impairment
Dosage adjustment is necessary based on renal function
In neonates, neutrophil counts should be monitored at least twice weekly
✔️ Storage Conditions
- Store below 25°C
- Protect from light and moisture
- Keep out of reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
