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Aproxi 125mg Capsule 1 Strip
Aproxi 125 is an anti-emetic used to prevent nausea and vomiting caused by chemotherapy in:
- Adults
- Adolescents (12 years and older)
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✅ Description:
Aprepitant is a selective, high-affinity antagonist of human substance P neurokinin 1 (NK1) receptors. Blocking these receptors prevents nausea and vomiting caused by chemotherapy or surgery.
- Do not take Aprifast if you are allergic to Aprepitant or its ingredients.
- Not recommended for children below 12 years.
- Pregnancy & Breastfeeding: Consult your doctor before use.
- Avoid driving if you feel dizzy or sleepy.
- Inform your doctor about all medications you are taking (prescription or non-prescription).
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✔️ Uses of Aproxi 125
Treatment of Chemotherapy-induced nausea and vomiting
✔️ How does Aproxi 125 work?
Aproxi 125 contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting.
✔️ Side Effects of Aproxi 125
- Headache
- Constipation
- Loss of appetite
- Tiredness
- Indigestion
- Hiccups
These side effects are usually mild and go away over time. However, inform your doctor if they persist or worsen.
✔️ Quick Suggestions:
- Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
- Increase the intake of fluids. Drink a small amount of water after small intervals to stay hydrated.
- Avoid taking greasy or oily foods, as these foods trigger nausea and vomiting.
✔️ Aproxi is used for the prevention of:
- Postoperative nausea and vomiting (PONV)
- Chemotherapy-induced nausea and vomiting (CINV)
✔️ Postoperative Nausea & Vomiting (PONV)
- 40 mg taken orally within 3 hours before anesthesia induction.
✔️ Chemotherapy-Induced Nausea & Vomiting (CINV)
For Highly Emetogenic Chemotherapy:
- Day 1: Aprepitant 125 mg, Dexamethasone 12 mg, Ondansetron 24 mg (30 minutes before chemotherapy).
- Day 2 & 3: Aprepitant 80 mg, Dexamethasone 8 mg.
- Day 4: Dexamethasone 8 mg only.
For Moderately Emetogenic Chemotherapy:
- Day 1: Aprepitant 125 mg, Dexamethasone 12 mg, Ondansetron 8 mg (one tablet 30 minutes before chemotherapy, another 8 mg dose after 8 hours).
- Day 2 & 3: Aprepitant 80 mg, Ondansetron 8 mg twice daily.
Aprepitant should be taken 1 hour before chemotherapy on Day 1 and in the morning on Days 2 and 3.
✔️ Aproxi affects CYP3A4 and CYP2C9 enzymes, so caution is needed when used with:
- CYP3A4 inhibitors: Ketoconazole, Itraconazole, Ritonavir, Clarithromycin, etc.
- CYP3A4 inducers: Rifampin, Carbamazepine, etc.
- CYP2C9 substrates: Warfarin, Phenytoin, Tolbutamide, etc.
Hormonal contraceptives may be less effective during and up to 28 days after the last dose. Backup contraception is recommended.
✔️ Contraindications
- Hypersensitivity to Aprepitant or any of its components.
- Should not be used with: Pimozide, Terfenadine, Astemizole, or Cisapride.
✔️ Overdose Effects
- No specific antidote.
- Possible symptoms: Drowsiness, headache.
- Hemodialysis cannot remove Aproxi from the body. Supportive care is recommended.
✔️ Renal impairment:
- No dose adjustment is required.
✔️ Hepatic impairment:
No dose adjustment for mild to moderate impairment. No data for severe cases.
✔️ Pregnancy & Lactation
- Pregnancy Category B – Use only if necessary.
- Unknown if excreted in breast milk; consider stopping the drug or breastfeeding based on necessity.
✔️ Storage Conditions
- Store below 30°C, away from light & moisture.
- Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
