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Apuldon 15ml Paediatric Drops
Domperidone is used for the treatment of Gastritis, Lactation, Migraine, Nausea and vomiting, Gastroparesis, and Non-ulcer dyspepsia. It blocks substances in the brain triggering nausea/vomiting and enhances stomach movement, improving digestion.
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✅ Description:
Indications of Apuldon:
- Delayed stomach emptying
- Gastroesophageal reflux
- Esophagitis
- Dyspeptic symptom complex
- Upper abdominal pain
- The feeling of abdominal distension
- Epigastric fullness
- Eructation
- Flatulence
- Early satiety
- Vomiting and nausea
- Regurgitation of stomach contents into the mouth
- Heartburn
- Dyspepsia without ulcers
- Acute nausea and vomiting of functional, organic, infectious, or dietetic origin
- Nausea and vomiting generated by radiotherapy or pharmacological therapy
- Nausea and vomiting induced in migraine
- Dopamine agonist-induced nausea and vomiting in Parkinson's disease
- Increasing the speed of barium transit in follow-up radiological tests.
Safety Advices
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Apuldon. Consult your doctor for guidance.
Pregnancy
CONSULT YOUR DOCTOR
Apuldon may be unsafe to use during pregnancy. Consult your doctor to weigh the benefits and potential risks.
Breastfeeding
SAFE IF PRESCRIBED
Apuldon is safe to use during breastfeeding. Consult your doctor, and human studies suggest it is not harmful to the baby.
Driving
CAUTION
Apuldon may decrease alertness, affect vision, or cause sleepiness and dizziness. Do not drive if these symptoms occur.
Kidney
CAUTION
Use Apuldon with caution in patients with kidney disease. Dose adjustment may be needed. Consult your doctor.
Liver
CAUTION
Apuldon should be used with caution in patients with liver disease. Dose adjustment may be needed. Use is not recommended in moderate and severe liver disease. Consult your doctor.
✔️ Uses of Apuldon 15ml Paediatric Drops
- Indigestion
- Nausea
- Vomiting
✔️ How does Apuldon 15ml Paediatric Drops work?
A prokinetic, it acts on the brain region controlling vomiting and increasing upper digestive tract movement.
✔️ Side Effects of Apuldon 15ml Paediatric Drops
- Use with caution in children due to an elevated risk of extrapyramidal effects.
- Caution in patients with hepatic impairment.
✔️ Quick Suggestions:
- Relieves nausea, vomiting, and indigestion.
- Take before meals, following the prescribed dose and duration.
- May cause dizziness; avoid activities requiring focus.
- Avoid alcohol consumption; worsens sleepiness.
- Manage dry mouth with mouth rinses and increased water intake.
- Inform your doctor of persistent side effects.
- Do not exceed 7 days of use without consulting your doctor.
✔️ Pharmacology
- Domperidone is a dopamine agonist.
- Blocks dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) in the stomach.
- Gastroprokinetic function inhibits dopamine receptors in the gastrointestinal tract, impacting motility.
- Poor penetration across the blood-brain barrier, avoiding psychotropic and neurologic adverse effects.
- Restores normal upper gastrointestinal motility and tone.
- Aids stomach emptying, improves antral and duodenal peristalsis, and modulates pylorus contraction.
- Inhibits gastric regurgitation by increasing esophageal peristalsis and lowering esophageal sphincter pressure.
✔️ Dosage & Administration of Apuldon 15ml Paediatric Drops
- Take 15-30 minutes before meals and, if necessary, before retiring.
- Usual oral dose for adults: 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily. Max dose: 80 mg daily.
- Usual oral dose for children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml pediatric drops/10 kg body weight, every 6-8 hours daily.
- Various doses for dyspeptic symptoms and acute/sub-acute conditions.
✔️ Interaction of Apuldon 15ml Paediatric Drops
- Bromocriptine's hypoprolactemic impact may be reduced.
- Antimuscarinics and opioid analgesics may counteract Domperidone's effect on GI function.
- Caution when used with MAO inhibitors.
✔️ Contraindications:
- Known hypersensitivity to the medicine or neonates.
- Gastrointestinal stimulation is a potentially harmful condition.
- Prolactin-releasing pituitary tumor.
✔️ Pregnancy & Lactation:
- Not recommended during pregnancy due to unknown safety.
- Teratogenic effect not shown in animal research.
- Secreted in breast milk but considered not dangerous.
✔️ Precautions & Warnings:
- Extreme caution in children and patients with hepatic impairment.
- Use with caution due to incomplete blood-brain barrier in youngsters.
✔️ Storage Conditions:
- Store at or below 30°C, away from light and moisture.
- Keep out of reach of children.
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
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lab tests, medicines, all possible side effects, drug interactions,
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and discuss all your queries related to any disease or medicine. We
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