Onaseron, a serotonin subtype 3 (5-HT3) receptor antagonist, is indicated for:
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Onaseron ODT Tablet contains Ondansetron, which belongs to a group of medicines called Anti-Nausea. It is used to manage nausea and vomiting induced by chemotherapy or radiotherapy. Onaseron ODT Tablet is also used after surgeries (operations) to manage nausea and vomiting.
Before taking the Onaseron ODT Tablet, inform your doctor if you have severe constipation, heart or liver problems, imbalance with the levels of salts in the blood, such as potassium, sodium, and magnesium, or have been scheduled for any surgery.
Onaseron ODT Tablet is not recommended for use during pregnancy. This medicine may pass through the breast milk hence it is not recommended during breastfeeding. Consult your doctor before taking this medicine.
The dose of Onaseron ODT Tablet will depend on your child's age, body weight, and disease condition. Dosage adjustment is not required in elderly patients, hence consult your doctor before taking Onaseron ODT Tablet.
Common side effects include headache, constipation, and diarrhea, usually mild to moderate. Rash, sensation of warmth, hiccups, and liver enzyme abnormalities have been reported. Rarely, anaphylaxis, bronchospasm, tachycardia, angina, hypokalemia, and shortness of breath may occur. Extrapyramidal reactions are very rare.
Ondansetron is a potent and highly selective 5-HT3 receptor antagonist. Its precise mode of action in controlling nausea and vomiting is not fully known. Chemotherapeutic agents and radiotherapy can release 5-HT in the small intestine, initiating a vomiting reflex via 5-HT3 receptors on vagal afferents. Ondansetron blocks this reflex. The release of 5-HT in the area postrema (brainstem) may also contribute to emesis through a central mechanism. Thus, ondansetron likely manages nausea and vomiting by antagonizing 5-HT3 receptors in both the peripheral and central nervous systems. The mechanism for post-operative nausea and vomiting may involve similar pathways.
It can be taken with or without a meal as advised by the doctor. Swallow the tablet as a whole with a glass of water. Do not break, crush, or chew it.
Onaseron is contraindicated in patients with hypersensitivity to the drug or its components and in those taking apomorphine
Animal studies have not shown evidence of harm to the fetus, but there are no adequate studies in pregnant women. Ondansetron is excreted in rat milk, so caution is advised when administering it to breastfeeding women
Hypersensitivity reactions have been reported in patients sensitive to other 5-HT3 antagonists. Onaseron should not replace nasogastric suction in cases of gastric or intestinal peristalsis issues. It may mask progressive ileus or gastric distension post-abdominal surgery or chemotherapy-induced nausea and vomiting.
Store below 30ºC in a dry place, protected from light and moisture.
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