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Ondansetron HCl is used for the Prevention of nausea and vomiting associated with chemotherapy, radiotherapy, surgery, gastroenteritis, and pregnancy.
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✅ Description:
Ondansetron is a potent, highly selective 5HT3 receptor antagonist. Its exact mechanism in controlling nausea and vomiting is not fully understood. Chemotherapy and radiotherapy can trigger the release of 5HT in the small intestine, which initiates a vomiting reflex by activating vagal afferents through 5HT3 receptors. Ondansetron blocks this reflex. Additionally, activation of vagal afferents can release 5HT in the area postrema on the floor of the fourth ventricle, promoting emesis via a central mechanism. Therefore, ondansetron likely manages nausea and vomiting induced by chemotherapy and radiotherapy by antagonizing 5HT3 receptors in both the peripheral and central nervous systems. While the mechanisms for postoperative nausea and vomiting are not entirely known, they may share pathways with those of cytotoxic-induced nausea and vomiting.
Safety Advices
Alcohol
UNSAFE
Avoid consuming alcohol while taking Ondansetron HCl as this medicine can interact with alcohol and may worsen the side effects.
Pregnancy
CONSULT YOUR DOCTOR
Ondansetron HCl is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects on the developing baby; however, there are limited human studies
Breastfeeding
CONSULT YOUR DOCTOR
Ondansetron HCl is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
SAFE
Ondansetron HCl does not usually affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Ondansetron HCl is safe to use in patients with kidney disease. No dose adjustment of Ondansetron HCl is recommended. However, inform your doctor if you have an underlying kidney disease. Limited information is available on patients taking this medicine for more than one day.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Ondansetron HCl in patients with liver disease. Please consult your doctor.
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✔️ Uses of Zofra Injection
A potent, highly selective 5HT3 receptor antagonist used to control nausea and vomiting.
✔️ How does Zofra Injection work?
Ondansetron works by blocking a natural substance called serotonin in the brain that causes nausea and vomiting.
✔️ Quick Suggestions:
- You should not administer it on your own.
- Ondansetron injection should be administered by a qualified healthcare professional in a clinical setting.
- Your doctor will determine an appropriate dose of this injection based on your clinical condition.
- Report any undesirable side effects to your doctor promptly.
- Tell your doctor about all your current medicines as well as your medical conditions before receiving this medicine.
✔️ Chemotherapy-Induced Nausea and Vomiting (CINV)
Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of cancer treatment. It can be severe and distressing, significantly affecting the patient's quality of life and treatment compliance. Ondansetron, a 5HT3 receptor antagonist, is used to treat nausea and vomiting caused by chemotherapy. It works by blocking serotonin, a natural substance that causes nausea and vomiting.
✔️ Postoperative Nausea and Vomiting (PONV)
Postoperative nausea and vomiting (PONV) occur immediately after surgery and can continue for a day or two. This condition can be triggered by medications like anesthetics used during surgery. Ondansetron is effective in treating PONV by blocking the action of serotonin in the brain, thereby reducing nausea and vomiting.
✔️ Radiation-Induced Nausea and Vomiting (RINV)
Radiation-induced nausea and vomiting (RINV) is a common side effect for cancer patients undergoing radiotherapy. Patients may feel sick during or for a short time after radiotherapy treatment. Ondansetron is used to manage RINV by preventing the action of serotonin, thus alleviating nausea and vomiting during radiotherapy sessions.
✔️ Dosage & Administration of Zofra Injection
Chemotherapy-Induced Nausea and Vomiting
- Adults & Pediatric (6 months to 18 years):
- Injection: Three 0.15 mg/kg doses, up to 16 mg per dose, infused intravenously over 15 minutes.
Radiotherapy-Induced Nausea and Vomiting
- Adults:
- Injection: Three 0.15 mg/kg doses, up to 16 mg per dose, infused intravenously over 15 minutes.
Postoperative Nausea and Vomiting
- Pediatrics:
- >40 kg: Injection: 4 mg.
- <40 kg: Injection: 0.1 mg/kg.
✔️ Interaction
- Tramadol: Ondansetron may reduce the analgesic effect.
- CYP3A4 Inducers (e.g., rifampicin): May reduce ondansetron levels/effects.
- QT-Prolonging Agents (e.g., antiarrhythmics): Concomitant use may cause additive QT interval prolongation.
- Cardiotoxic Drugs (e.g., anthracyclines): May increase the risk of arrhythmias.
- Apomorphine: This may increase the hypotensive effect, potentially fatal.
✔️ Contraindications
Hypersensitivity to the drug or components, and concomitant use with apomorphine.
✔️ Pregnancy & Lactation
- No harm to the fetus in animal studies, but insufficient data for pregnant women.
- Lactation: Excreted in rat milk; caution in nursing women
✔️ Precautions & Warnings
- Hypersensitivity reactions.
- Not a replacement for gastric or intestinal peristalsis.
- May mask ileus or gastric distension.
✔️ Storage Conditions:
- Keep the medicine out of reach of children
- Store Zofra Injection at room temperature
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