Candistin Ear Drops 10ml

Uses of Candistin Ear Drops

• Treatment of Ear infection

How to use Candistin Ear Drops

• To apply, tilt the head to one side so that the ear is facing up.
• Then gently pull the ear lobe up & backward in case of adults and children older than 3 years.
• In the case of pediatric patients gently pull the ear lobe down & backward.

Side Effects of Candistin Ear Drops

• Ear discomfort
• Irritation at the application site

Quick Suggestions:

• Your doctor has prescribed Lidocaine + Clotrimazole + Beclometasone + Ofloxacin for the treatment of ear infections.
• Finish the prescribed dose even if you feel better as stopping the treatment earlier may reverse the symptoms.
• Do not touch the tip of the dropper, or of your ear to prevent contamination.
• Inform your doctor if you notice mild irritation in the ear, dizziness, headache, earache, or changes in taste may occur.
• Make sure to use it within 4 weeks of opening the bottle.

Pharmacology

Ofloxacin: It is a fluoroquinolone antibiotic effective against a broad spectrum of bacteria commonly found in otic infections. Ofloxacin works by inhibiting the bacterial DNA gyrase, thereby preventing bacterial replication. It is active against both Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Moraxella catarrhalis, Proteus mirabilis, and Pseudomonas aeruginosa. Importantly, it does not cause ototoxicity, making it preferable over aminoglycosides in middle ear infections.

Clotrimazole: This synthetic imidazole derivative acts as a broad-spectrum antifungal agent, targeting fungi responsible for superficial mycotic infections affecting the outer or middle ear, such as Candida, Microsporum, and Trichophyton. Clotrimazole inhibits the synthesis of ergosterol, a crucial component of the fungal cell wall, leading to compromised cell wall integrity and inhibited fungal growth. Additionally, it exhibits antibacterial activity against certain bacteria like Streptococci and Staphylococci, making it effective against mixed bacterial-fungal infections.

Beclomethasone Dipropionate: As a potent corticosteroid, beclomethasone exerts anti-inflammatory, antipruritic, and vasoconstrictive effects. It works by inducing phospholipase A2 and subsequently inhibiting the release of arachidonic acid, leading to suppression of the formation, release, and activity of inflammatory mediators such as prostaglandins and leukotrienes. This helps alleviate inflammation and associated symptoms in the ear.

Lidocaine Hydrochloride: Lidocaine is a local anesthetic that acts by blocking pain signals from the nerves to the brain, thereby reducing pain and stinging sensations in the ear.

The recommended dosage instructions for Candistin Ear Drops are as follows:

For Adults and Children: Instill 2-5 drops into the affected ear(s) three to four times daily.

For Otitis Externa with intact tympanic membrane: Suitable for individuals aged 6 months and older.

For Chronic Suppurative Otitis Media with perforated tympanic membrane: Recommended for individuals aged 12 years and older.

The treatment duration typically spans 7 to 14 days.

Interaction

• Lidocaine + Clotrimazole + Beclometasone + Ofloxacin may interact with various medications including painkillers (such as acetaminophen, aspirin, ibuprofen, naproxen, celecoxib, diclofenac, indomethacin, and meloxicam), corticosteroids (like prednisone), anti-diabetic drugs (such as insulin), respiratory medications (like theophylline), blood thinners (such as warfarin), diuretics (water pills), antidepressants, and antacids containing calcium, magnesium, or aluminum.
• Regarding drug-food interactions, none have been found or established. However, it's advisable to avoid fatty foods, alcohol, and caffeine as they can effectively manage infections.
• For drug-disease interactions, inform your doctor if you have a medical history of allergic reactions to medications, diabetes, liver diseases, cataract, glaucoma, or adrenal gland problems before using Lidocaine + Clotrimazole + Beclometasone + Ofloxacin.

Contraindications

Candistin Ear Drops is contraindicated in patients with sensitive to Ofloxacin or other quinolone, or to any of the components of this medications. It is contra-indicated in viral infections of the ear.

Pregnancy & Lactation

Safety during pregnancy or lactation has not been established. It is not known whether the active substances pass into breast milk when applied topically. Therefore, the potential benefit of this product during pregnancy or lactation, should be weighed against possible hazard to the fetus or the nursing infant.

Precautions & Warnings

Before using Candistin Ear Drops, inform your doctor about your medical history, including any liver or kidney diseases, adrenal gland problems, cataract, glaucoma, diabetes, or allergic reactions to the medication. If you are planning to become pregnant, already pregnant, or a lactating mother, consult your doctor before using this medication. Avoid self-medication with Candistin Ear Drops to prevent antibiotic resistance, which could render antibiotics ineffective against specific bacterial infections.

Storage Conditions:

Store below 30°C