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Genacyn 0.3% Eye/Ear Drops 10ml
Genacyn 0.3% Eye/Ear Drops is an antibiotic instilled in the eye to treat bacterial infections of the eye (eg. conjunctivitis). Additionally, it may be instilled in the ear to treat bacterial infections of the ear (eg. otitis externa).
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✅ Description:
- Eye: Treats bacterial infections such as blepharitis, blepharoconjunctivitis, conjunctivitis, dacryocystitis, keratitis, keratoconjunctivitis, acute meibomianitis, and corneal ulcers caused by susceptible organisms.
- Ear: Treats otorrhea associated with external otitis, chronic suppurative otitis media, subacute purulent otitis media, and postoperative otorrhea (e.g., after fenestration, mastoidectomy, tympanoplasty).
✔️ Uses of Genacyn 0.3% Eye/Ear Drops
Uses of Nicogenta Eye/Ear Drops
- Bacterial eye/ear infections
✔️ Side Effects
- Common: Itching, redness, swelling, burning sensation, stinging, increased redness, lacrimation, and transient irritation.
- Serious: Bacterial and corneal ulcers, ocular burning and irritation, nonspecific conjunctivitis, conjunctival epithelial defects, and conjunctival hyperemia.
✔️ Quick Suggestions:
- Follow your doctor’s instructions for use precisely.
- Do not skip doses and complete the full course of treatment.
- Avoid touching the dropper tip to any surface to prevent contamination.
- Wait at least 5-10 minutes before applying other medications in the same eye/ear.
- Inform your doctor if symptoms do not improve within two days of starting treatment.
- Do not wear contact lenses while using this medication for an eye infection.
✔️ Pharmacology
Gentamicin is an aminoglycoside antibiotic that binds to the 30S subunit of bacterial ribosomes, disrupting protein synthesis and effectively killing bacteria. It is active against a wide range of Gram-positive and Gram-negative bacteria.
✔️ Dosage & Administration
- Eye:
- Adults and Children: Instill 1-2 drops into the affected eye up to 6 times a day. For severe infections, initially instill 1-2 drops every 15-20 minutes, then reduce the frequency as the infection is controlled.
- Ear:
- Adults and Children: Clean the area and instill 2-3 drops into the affected ear 3-4 times a day and at night, or more frequently if required.
✔️
Interactions
- Additive Effect with Neurotoxic and Nephrotoxic Drugs: Including cephalosporins, methicillin, amphotericin B, ciclosporin, cisplatin, potent diuretics (e.g., ethacrynic acid, furosemide).
- Potentiation of Anticoagulants: May enhance the effects of anticoagulants like warfarin and phenindione.
- Antagonistic Effects: May reduce the effectiveness of neostigmine and pyridostigmine.
- Increased Risk of Neuromuscular Blockade: With botulinum toxin.
- Indometacin: May increase plasma concentration of Gentamicin in neonates.
✔️ Contraindications
- Hypersensitivity to Gentamicin or any component of the product.
- Use is contraindicated in pregnancy and patients with myasthenia gravis.
- Not for injection. Do not use subconjunctivally or directly in the anterior chamber of the eye.
✔️ Pregnancy & Lactation
- Pregnancy: Category D. Gentamicin may cause fetal ototoxicity. The safety profile for eye/ear drops in pregnancy is not established; use only if essential.
- Lactation: Small amounts of Gentamicin have been detected in breast milk; breastfeeding should be discontinued during treatment.
✔️ Precautions & Warnings
- Use cautiously in patients with conditions predisposing them to ototoxicity and nephrotoxicity.
- Monitor plasma concentrations in patients receiving high doses or prolonged courses, especially in infants, the elderly, and patients with renal impairment, cystic fibrosis, or significant obesity.
- Monitor auditory and renal functions.
- Avoid contamination by not touching the tip of the dropper to any surface.
✔️ Storage Conditions
- Store below 30°C, protected from light and moisture.
- Keep out of reach of children.
- Use within 4 weeks of opening the bottle.
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