Gelora Oral Gel

✔️ Uses of Gelora Oral Gel

• Infections

✔️ How does Gelor? Oral Gel work?

Miconazole is an antifungal medication that treats skin infections. It works by killing the fungi on the skin by destroying their cell membrane.

✔️ Side Effects of Gelora Oral Gel 2%

• Skin Rash
• Change In Skin Color
• Dry Or Scaly Skin
• Skin Blistering
• Redness Of Skin
• Itching Of Skin
• Wrinkled And Rough/Mottled Skin
• Burning Or Tingling Sensation Of Skin
• Photosensitivity Of Skin
• Skin Thinning
• Skin Redness

✔️ Quick Suggestions:

• Your doctor has prescribed Miconazole to cure your infection and improve symptoms.
• Some tips for personal hygiene:
  
  • Wash your hands with soap before and after applying the cream.
  • Do not share your towel or clothes with anyone.
  • Wear clean clothes every day to prevent infection.
• Apply an amount sufficient to cover the affected area and 1 inch of the immediate surrounding skin.
• Treatment may be needed for 2 to 6 weeks for skin infections and 6 weeks to 6 months for nail infections.
• Do not skip any doses and finish the full course of treatment even if you feel better.
• Avoid getting it in the eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water.

Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. 

✔️ Indication OF Gelora Oral Gel

Oral treatment and prevention of fungal infections of the oropharynx and gastrointestinal tract, and of super infections due to Gram-positive bacteria.

✔️ Pharmacology

Pharmacodynamics: Miconazole exhibits antifungal activity against common dermatophytes and yeasts. It also has antibacterial action against certain gram-positive bacilli and cocci. The main mechanism of action involves the inhibition of a demethylation step in ergosterol biosynthesis, a crucial process for fungal growth. Ergosterol is an essential component of the fungal cell membrane, and its disruption leads to the formation of gaps in the cell membrane. This disruption allows essential constituents of the fungal cells to leak out, eventually causing the death of the fungal cells.

Pharmacokinetics: When administered orally, Miconazole has low bioavailability (25-30%) due to limited absorption from the intestinal tract. After administration as an oral gel, Miconazole is systemically absorbed. Once absorbed, the majority of Miconazole is bound to plasma proteins (88.2%), primarily to serum albumin and red blood cells (10.6%). The absorbed portion of Miconazole is extensively metabolized in the body. Only a very small amount (less than 1%) of the administered dose is excreted unchanged in the urine. The terminal plasma half-life of Miconazole is around 20-25 hours in most patients. The elimination half-life of Miconazole remains similar in patients with renal impairment.

✔️ Dosage & Administration of Gelora Oral Gel

The administration of Gelora Oral Gel is specific to the affected area in the mouth or throat. Here are the recommended doses for both adults and children:

Adult Dose:

• Oropharyngeal candidiasis and Intestinal candidiasis: The usual dose is 15 mg/kg/day in divided doses. For this gel formulation, one or two teaspoons (5-10 ml) of gel should be taken four times daily. It is recommended to continue treatment for at least 1 week after the symptoms have disappeared.
• For localized lesions of the mouth: A small amount of gel should be applied directly to the affected area with a clean finger four times daily for 5-7 days.

Child Dose:

• Oropharyngeal candidiasis:
  • Children aged 6 years and over One teaspoonful (5 ml) of gel four times daily.
  • Children aged 2-6 years: One teaspoonful (5 ml) of gel twice daily.
  • Infants under 2 years: Half teaspoonful (2.5 ml) of gel twice daily.
  • Treatment should be continued for at least 1 week after the symptoms have disappeared.
• For localized lesions of the mouth:
  • Smear a small amount of gel on the affected area with a clean finger four times daily for 5-7 days.

It is important to follow the prescribed dosages and treatment duration as recommended by the healthcare provider. For oropharyngeal candidiasis and intestinal candidiasis, the gel should be retained in the mouth for as long as possible before swallowing. The gel can be directly applied to localized lesions in the mouth using a clean finger. If symptoms persist or worsen, it is essential to consult a healthcare professional for further evaluation and management.

✔️ Interaction

Drug-Drug Interactions: 

• Gelora Oral Gel may interact with anticoagulant drugs such as anisindione, dicoumarol, and warfarin. It's essential to inform your doctor if you are taking any of these medications to avoid potential interactions.

Drug-Food Interactions: 

• Avoid consuming caffeine-containing drinks like tea, coffee, cola, and energy drinks while using Gelora Oral Gel15 gm, as it may increase the adverse effects of caffeine.
• Do not take marijuana with Gelora Oral Gel 15 gm, as it may worsen the adverse effects of marijuana.
• Avoid consumption of alcohol with Gelora Oral Gel 15 gm, as it may increase the risk of liver damage.

Drug-Disease Interactions: 

• Inform your doctor before using Gelora Oral Gel 15 gm if you have asthma, sulfite allergy, an autoimmune disorder, or heart or liver problems, as these conditions may require special considerations while using the medication.

✔️ Contraindications

Gelora Oral Gel 15 gm may be contraindicated in patients with known hypersensitivity (e.g., anaphylaxis) to miconazole, milk protein concentrate, or any other component of the product. If you have a history of severe allergic reactions to miconazole or related products, avoid using Gelora Oral Gel 15 gm.

✔️ Pregnancy & Lactation

The safety of Miconazole oral gel during pregnancy has not been established through clinical studies. Therefore, it is generally recommended to avoid using Miconazole oral gel in pregnant women, especially during the first trimester when fetal development is most critical. If there is a need to use the medication during pregnancy, the potential risks should be carefully assessed and balanced against the possible benefits under the supervision of a healthcare professional.

Similarly, caution should be exercised when using Miconazole oral gel in nursing women. Since many drugs can be excreted in human breast milk, it is essential to consider the potential risks to the infant before using this medication while breastfeeding. If the use of Miconazole oral gel is deemed necessary, it should be done under the guidance of a healthcare provider to ensure the safety of both the mother and the infant.

As always, it is crucial for pregnant or breastfeeding women to discuss their medical condition with their healthcare provider before using any medication to make informed and safe decisions.

✔️ Precautions & Warnings

• Allergy: Inform your doctor if you are allergic to miconazole or any other antifungal agents before using Gelora Oral Gel 15 gm.
• Weakened Immune System: Use Gelora Oral Gel 15 gm with caution if you have a weakened immune system due to conditions like HIV, or AIDS, or if you are receiving chemotherapy.
• Diabetes: If you have diabetes, inform your doctor before using Gelora Oral Gel 15 gm.
• Pregnancy and Breastfeeding: Inform your doctor if you are pregnant or breastfeeding before using Gelora Oral Gel 15 gm.
• Eye Contact: Keep Gelora Oral Gel 15 gm away from your eyes. If the cream accidentally gets into your eyes, rinse immediately with water and keep your eyes open while rinsing.

✔️ Storage Conditions

keep in a dry put absent from light and warm. Keep out of the reach of children.