GEL, Generic Name: Clindamycin Phosphate 1.2 % +Tretinoin 0.025 %, Manufacturer: Incepta Pharmaceuticals Ltd.
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Clindamycin with Tretinoin gel is used to treat acne vulgaris on a topical basis.
Clindamycin phosphate, a lincosamide antibiotic, is combined with Tretinoin, a retinoid. Clindamycin binds to the 50s ribosomal subunit of sensitive bacteria, preventing peptide chain elongation and inhibiting bacterial protein synthesis by interfering with peptidyl transfer. Clindamycin decreases the incidence of acne by inhibiting the action of Propionibacterium acne. Tretinoin reduces the cohesion of follicular epithelial cells and promotes turn over, causing comedones to emerge.
Before sleep: Wash the face gently with a mild soap and water, then pat the skin dry. Apply the Gel with finger tips through the face gently.
In the morning: Apply a sunscreen after the application of Gel. Do not wash your face more than 2 or 3 times a day. Apply the sunscreen cream as needed.
Safety and effectiveness in children below 12 years of age have not been established.
Individuals who are hypersensitive to Clindamycin, Tretinoin, or any other component of the Gel should not be given Clindamycin or Tretinoin.
The most frequent adverse effects include erythema, scaling, nasopharyngitis, dry skin, cough, sinusitis, and diarrhea.
Clindamycin and Tretinoin are not known to be excreted in human milk. When using Clindamycin or Tretinoin on a breastfeeding woman, use extreme care.
Clindamycin with Tretinoin should not be used to treat infections of the eyes, nose, ear, lips, cut, or burn. Keep the Gel out of direct sunlight once it has been applied.
Topical antibiotic & retinoid preparations
Keep the temperature below 25°C and away from light and moisture. Keep out of children's reach.
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