Ointment Manufacturer/Distributor: General Pharmaceuticals Ltd. Generic Name: Fluticasone Propionate 0.005% Ointment
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Indications
Fluticasone propionate is used to relieve inflammation and itchy manifestations of eczema / dermatitis that is responsive to corticosteroids.
Pharmacology
Fluticasone propionate is a glucocorticoid with high local anti-inflammatory activity, but low HPA axis inhibitory activity after transdermal administration. Hence, it has a higher therapeutic index than the most commonly available steroids. Fluticasone propionate has a high degree of selectivity for the glucocorticoid receptor. In vitro studies have shown that fluticasone propionate has high affinity and agonist activity at human glucocorticoid receptors. This receptor would be responsible for the anti-inflammatory properties of glucocorticoids. Fluticasone propionate has a low affinity for the progesterone receptor, and almost no affinity for the mineralocorticoid, estrogen, or androgen receptor. The therapeutic efficacy of glucocorticoids is related to the half-life of the glucocorticoid receptor complex. The half-life of fluticasone propionate is glucocorticoid receptor complex approximately 10 hours.
Dosage & Administration
Cream: Apply a thin layer of Fluticasone propionate cream to the affected skin areas once daily.
Ointment: Apply a thin layer of Fluticasone propionate Ointment to the affected skin areas twice daily.
Contraindications
Fluticasone propionate is contraindicated in rosacea, acne, perioral dermatitis, primary viral skin infections (eg, herpes simplex, chickenpox), hypersensitivity to any ingredient, perianal itching. and genitals, etc. The use of fluticasone propionate is not indicated for the treatment of infected skin lesions primarily caused by fungal or bacterial infections and skin diseases in children under one year of age, including dermatitis and skin rashes.
Side Effects
Fluticasone propionate preparations are generally well tolerated; Local burning and itching have been reported. If there are signs of hypersensitivity, stop use immediately. Prolonged and intensive treatment with potent corticosteroid preparations can cause local skin atrophy, including thinning, dermatoglyphs, superficial vasodilation, hirsutism, and hypopigmentation.
Secondary infections, especially when it comes to the use of occlusive dressings or skin folds, there are also reports that the use of corticosteroids can cause allergic contact dermatitis. Corticosteroid use has been reported to worsen the signs and symptoms of skin conditions.
Prolonged use of large amounts of corticosteroids or treatments over large areas can lead to adequate systemic absorption, resulting in the characteristics of hypercortical function. If an occlusive dressing is used, this effect is more likely to occur in infants and children. In babies, napkins can serve as occlusive dressings.
Pregnancy & Lactation
Use of fluticasone propionate during pregnancy should only be considered if the expected benefit to the mother outweighs any possible risk to the fetus. Excretion of fluticasone propionate in breast milk has not been studied. Plasma concentrations in patients following transdermal application of fluticasone propionate at the recommended dose may be low. When fluticasone propionate is administered to a nursing woman, the benefits of treatment should be weighed against the possible risks to the mother and child.
Precautions & Warnings
Fluticasone propionate has a very low tendency for systemic absorption. However, prolonged use of high doses over large areas of the body surface, especially in infants and young children, may lead to adrenal suppression. Children may absorb proportionally larger amounts of topical corticosteroids and are therefore more susceptible to systemic toxicity. The face, more than other areas of the body, may atrophy after prolonged treatment with potent topical corticosteroids. This should be borne in mind when treating severe eczema. Appropriate antibacterial therapy should be used when treating infected inflammatory lesions. Any spread of infection requires discontinuation of topical corticosteroid therapy and systemic administration of antibacterial agents. Bacterial infections are caused by hot and humid conditions caused by occlusive dressings, and therefore, the skin needs to be cleaned before applying new dressings.
Therapeutic Class
Fluticasone & combined preparations topical
Storage Conditions
Store below 30°C.Do not freeze.
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