Niagra 50mg Tablet-8pcs Box

✔️ Uses of Niagra 50mg Tablet

• Treats erectile dysfunction

✔️ How does Niagra 50mg Tablet work?

Niagra 50mg Tablet enhances penile erection (firmness of the penis) during sexual intercourse, whilst sildenafil works by increasing blood flow to the penis. It acts by inhibiting the actions of certain enzymes (PDE5) that restrict blood flow to the penis. As a result, it relaxes the blood vessels feeding the penis, increases penile function, and keeps it erect during sexual contact.

✔️ Side Effects of Niagra 50mg Tablet

• Flushing
• Indigestion
• Headache, dizziness
• Stuffy nose
• Effects on vision (includes light sensitivity, blurred vision, color tinge to vision, reduced sharpness of vision, or visual disturbance)
• Nausea

✔️ Quick Suggestions:

• You've been prescribed Niagra 50mg Tablet to treat erectile dysfunction.
• It's advised to take it one hour before sexual activity. You can, however, take it between 30 minutes and 4 hours before sexual activity.
• Take it no more than once per day.
• Seek medical assistance if the erection lasts longer than four hours following sexual contact.
• If you have recently taken nitrates (medicines used to treat angina or chest discomfort), do not take Niagra 50.
• If you've had a heart attack in the last three months, or a stroke or heart failure in the last six months, don't take it.

✔️ Indication of Niagra 50mg Tablet

Sildenafil, which is included in Niagra 50mg Tablet, belongs to a class of drugs known as Phosphodiesterase type 5 (PDE 5) inhibitors. It is used to treat male erectile dysfunction. Erectile dysfunction (also known as impotence) is a sexual disorder in which a man is unable to maintain the firm erected penis essential for regular sexual engagement. It occurs as a result of reduced blood flow to the penis caused by constriction of the blood capillaries feeding the penis.

✔️ Pharmacology

Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and is used to treat erectile dysfunction. Danafil (sildenafil) enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cGMP in the cavernous body, leading to smooth muscle relaxation and blood flow to the sponge Body.

✔️ Dosage & Administration of Niagra 50mg Tablet

• For adults without renal impairment, the recommended dosage of (Sildenafil) Niagra 50mg Tablet is taken approximately one hour before sexual activity. However, it can be taken anywhere between 30 minutes to 4 hours before sexual activity. The dose can be increased to a maximum of 100 mg or decreased to 25 mg based on individual response and tolerance. It's important not to exceed the maximum recommended dose and to take it no more than once within a 24-hour period.
• In elderly individuals aged 65 years or older, a lower initial dose of 25 mg is recommended.
• In cases of hepatic impairment (liver problems), the initial dose should also be 25 mg.
• For the treatment of pulmonary arterial hypertension, the recommended dose is 20 mg taken three times daily, with each dose administered 4 to 6 hours apart.
• For individuals with renal impairment and creatinine clearance (CrCl) of less than 30 mL/min, the initial recommended dose is also 25 mg.
• It's important to note that the specific dosing instructions and adjustments may vary depending on individual circumstances, and it's always best to consult with a healthcare professional or doctor for personalized dosing recommendations to ensure the safe and effective use of sildenafil.

✔️ Interaction

Inhibitors of CYP3A4: Medications such as cimetidine and erythromycin, which are CYP3A4 inhibitors, can reduce the clearance of sildenafil from the body. This can result in increased levels of sildenafil in the bloodstream, potentially leading to an increased risk of side effects.

CYP3A4 inducers: Rifampicin, a CYP3A4 inducer, may decrease the plasma concentrations of sildenafil. This means that rifampicin can lower the levels of sildenafil in the body, potentially reducing its effectiveness.

Beta-blockers: When Niagra 50mg Tablet is used concomitantly with beta-blockers, there is a potential risk of symptomatic hypotension (low blood pressure). Both medications can independently cause a decrease in blood pressure, and the combination may have an additive effect, leading to a significant drop in blood pressure.

Ritonavir: Ritonavir, a medication used for the treatment of HIV infection, can increase the plasma concentrations of sildenafil. This means that ritonavir can enhance the effects of sildenafil and potentially increase the risk of side effects.

Organic nitrates and nicorandil: Niagra 50mg Tablet should not be used in combination with organic nitrates (such as nitroglycerin) or nicorandil. The concurrent use of these medications can potentiate the hypotensive effects of Niagra 50mg Tablet, leading to a severe drop in blood pressure, which can be potentially life-threatening.

✔️ Contraindications

Niagra 50mg Tablet  (sildenafil) is contraindicated in individuals with hypersensitivity to sildenafil or any of the other components of the medication. If a person has a known allergy or hypersensitivity to sildenafil, they should not use Niagra 50mg Tablet.

Additionally, the use of Niagra 50mg Tablet is contraindicated in patients who are concurrently or intermittently using organic nitrates in any form. Organic nitrates are commonly prescribed for the treatment of angina (chest pain) and include medications such as nitroglycerin. The combination of Niagra 50mg Tablet with organic nitrates can cause a significant drop in blood pressure, leading to a potentially dangerous condition known as hypotension. Therefore, it's important to avoid the simultaneous use of Niagra 50mg Tablet and organic nitrates.

✔️ Pregnancy & Lactation

Sildenafil is not suitable for women.

✔️ Precautions & Warnings

• Anatomical deformation of the penis: Patients with anatomical deformations of the penis, such as Peyronie's disease, should use sildenafil with caution. The medication may potentially exacerbate or worsen the condition. It's important to discuss this with a healthcare professional before starting treatment.
• Conditions predisposing to priapism: Sildenafil can increase the risk of priapism, which is a prolonged and painful erection. Patients with conditions that may predispose them to priapism, such as sickle cell anemia, multiple myeloma, or leukemia, should use sildenafil with caution. If an erection lasts longer than four hours, medical assistance should be sought immediately to prevent potential complications.
• Impairment of color discrimination: Sildenafil can cause mild and transient impairment of color discrimination, particularly affecting the ability to differentiate between blue and green hues. This effect is usually dose-related and temporary, resolving after the medication is cleared from the body.
• Pre-existing medical conditions: Sildenafil should be used cautiously in patients with hepatic (liver) or severe renal (kidney) impairment, bleeding disorders, active peptic ulceration, hypotension (low blood pressure), recent history of stroke or heart attack, arrhythmias (abnormal heart rhythms), unstable angina, heart failure, or retinal disorders. These conditions may increase the risk of complications or limit the safe use of sildenafil.
• Sudden loss or decrease in hearing: In rare cases, sildenafil has been associated with sudden hearing loss or a decrease in hearing ability. If any changes in hearing occur while taking sildenafil, medical attention should be sought promptly.

✔️ Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.