Tiagra 5mg Tablet

✔️ Uses of Tiagra 5mg Tablet

Erectile dysfunction (impotence), benign prostatic hyperplasia (BPH), Pulmonary arterial hypertension (PAH)

✔️ How does Tiagra 5mg Tablet work?

Tiagra 5mg Tablet is a phosphodiesterase (PDE-5) inhibitor. It works in erectile dysfunction by increasing blood flow to the penis by relaxing the muscles in penile blood vessels. Tiagra 5mg Tablet also relaxes or widens the blood vessels inside the lungs. When the blood vessels relax and widen, it’s easier for the heart to pump blood through the lungs, which reduces blood pressure in the lungs.

✔️ Side Effects of Tiagra 5mg Tablet

Common side effects include headache, dyspepsia, back pain, myalgia, nasal pharyngitis, and nasal congestion. Rare but possible complications may include changes in color vision, sudden vision loss, hearing loss, Stevens-Johnson Syndrome, exfoliative dermatitis, angina, stroke, myocardial infarction, severe hypotension, and tachycardia.

✔️ Quick Suggestions:

• It is best to take it an hour before sexual intercourse. But, you can take it anytime between 30 minutes and 4 hours before sexual activity.
• Do not take it more than once a day.
• It may also be used for treating the urinary symptoms of an enlarged prostate gland (benign prostatic hyperplasia).
• It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
• Avoid drinking alcohol as it can reduce your ability to get an erection and can make dizziness worse.
• Seek medical attention if the erection persists for more than 4 hours after sexual intercourse.
• Do not use Tadalafil if you have recently taken nitrates (medicines used in angina or chest pain), if you have had a heart attack in the past 3 months, or stroke or heart failure in the past 6 months.

✔️ Indication

Erectile dysfunction (ED) refers to the inability to achieve or maintain an erection sufficient for sexual intercourse. It can be caused by physical or psychological factors such as anxiety, depression, low self-esteem, or stress. Certain lifestyle factors like smoking, alcohol consumption, obesity, physical inactivity, and high blood pressure can contribute to ED. Symptoms of ED include difficulty in achieving an erection, trouble maintaining it during sexual activity, and reduced sexual desire.

Benign prostatic hyperplasia (BPH), also known as prostate enlargement, is the non-cancerous growth of the prostate gland due to the multiplication of cells. This growth can lead to the swelling and constriction of the urethra, resulting in urinary difficulties. BPH is typically associated with aging and can cause issues like loss of bladder control, frequent urination, difficulty initiating urination, incomplete emptying of the bladder, a weak urinary stream, dribbling at the end of urination, sudden urges to urinate, and painful urination.

Tiagra 5mg Tablet is used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH). Sometimes, Tiagra 5mg Tablet is also used to treat pulmonary arterial hypertension (high blood pressure in the lungs). 

✔️ Pharmacology

Tadalafil is a specific inhibitor of phosphodiesterase type 5 (PDE5). PDE5 inhibition raises cGMP levels in smooth muscle cells. Smooth muscle relaxation and increased blood flow into the corpus cavernosum are both caused by cGMP, resulting in penile erection. PDE5 is also found in the prostate and bladder wall smooth muscles. PDE5 inhibition raises cGMP levels, causing smooth muscle relaxation in the prostate and bladder. Smooth muscle relaxation may enhance blood flow to the urinary system and widen the bladder neck opening, resulting in better voiding.

✔️ Dosage & Administration of Tiagra 5mg Tablet

Adult Dose:

For Erectile Dysfunction (Use as Needed):

• The recommended starting dose is 10 mg taken before anticipated sexual activity.
• Depending on individual efficacy and tolerability, the dose can be increased to 20 mg or decreased to 5 mg.
• The maximum recommended dosing frequency is once per day for most patients.

For Once Daily Use (Erectile Dysfunction):

• The recommended starting dose for once-daily use is 2.5 mg, taken at approximately the same time every day.
• The dose can be increased to 5 mg based on individual efficacy and tolerability.

For Benign Prostatic Hyperplasia (BPH):

• The recommended dose is 5 mg taken once daily.

For BPH with Erectile Dysfunction:

• The recommended dose is 5 mg taken once daily, at approximately the same time each day, without regard to the timing of sexual activity.
• When used in combination with finasteride for BPH, take Tadalafil 5 mg plus finasteride 5 mg once daily for less than 26 weeks.

For Pulmonary Arterial Hypertension:

• The recommended dose is 40 mg taken once daily.
• Dividing the dose for more frequent dosing is not recommended.
• Patients also taking ritonavir may start with 20 mg once daily initially for more than one week and may increase the dose to 40 mg per day based on tolerability.

Hepatic Impairment (Erectile Dysfunction):

• For mild-to-moderate hepatic impairment (Child-Pugh class A or B), the dose should not exceed 10 mg once daily.
• Tadalafil is not recommended for severe hepatic impairment (Child-Pugh class C).

Hepatic Impairment (Pulmonary Arterial Hypertension):

• For mild-to-moderate hepatic impairment (Child-Pugh class A or B), consider starting with a dosage of 20 mg once daily.
• Avoid the use of Tadalafil in severe hepatic impairment (Child-Pugh class C).

Renal Dose (Erectile Dysfunction):

• For mild renal impairment (CrCl >51 mL/min), no dosage adjustment is needed.
• For moderate renal impairment (CrCl 30-50 mL/min), the initial dose should not exceed 5 mg once daily, and the maximum dosage is 10 mg every 48 hours.
• For severe renal impairment (CrCl <30 mL/min) in patients on hemodialysis, the dose should not exceed 5 mg every 72 hours.

Renal Dose (Pulmonary Arterial Hypertension):

• For mild-to-moderate renal impairment (CrCl 31-80 mL/min), start with 20 mg once daily initially, and it may be increased to 40 mg once daily based on tolerability.
• Avoid the use of Tadalafil in severe renal impairment (CrCl <30 mL/min) in patients on hemodialysis.

Administration:

• Tadalafil may be taken with or without food.
• Sexual stimulation is required for Tadalafil to be effective.
• It can be taken between 30 minutes to 12 hours before anticipated sexual activity.
• The efficacy of Tadalafil may last up to 24 hours after taking the dose.

✔️ Interaction

Tadalafil may interact with various medications, including nitrates (e.g., Isosorbide, Nitroglycerin), alpha-adrenergic blockers, antihypertensives, alcohol, antacids (magnesium hydroxide/aluminum hydroxide), ketoconazole, ritonavir, erythromycin, itraconazole, grapefruit juice, other HIV protease inhibitors, rifampin, carbamazepine, phenytoin, and phenobarbital.

✔️ Contraindications

Hypersensitivity reactions to Tadalafil

✔️ Pregnancy & Lactation

Tadalafil is categorized as pregnancy category B by the US FDA, and its use during pregnancy should be based on a risk-benefit assessment. There is no information regarding Tadalafil excretion in human milk, so caution is advised when administering it to nursing mothers.

✔️ Precautions & Warnings

Caution is necessary when using Tadalafil in individuals with angina, renal impairment, hepatic impairment, and bleeding in conjunction with nitrates, alpha-blockers, alcohol, CYP3A4 inhibitors (e.g., ritonavir, ketoconazole, itraconazole), and other PDE5 inhibitors.

✔️ Storage Conditions

Store in a dry place, away from light and heat, and keep out of children's reach.