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Zif-A Tablet 10pcs
This combination supplement is used to address deficiencies in iron, folic acid, and zinc, often required during physiologically stressful conditions like pregnancy, lactation, and anemia. It provides essential nutrients for hemoglobin synthesis, erythropoiesis, and immune support.
- Treatment of Deficiencies:
- Iron deficiency anemia
- Folic acid and zinc deficiencies
- Prophylaxis:
- Preventing iron and zinc deficiency during pregnancy and lactation
- Dietary supplementation when nutrient intake is insufficient
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✅ Description:
Ferrous Ascorbate (Iron + Ascorbic Acid)
- Structure and Stability:
- Ferrous ascorbate is a stable complex combining iron (Fe²⁺) with ascorbic acid (Vitamin C).
- It does not dissociate in the gastrointestinal (GI) tract, ensuring efficient absorption and reducing the inhibitory effects of food on iron uptake.
- Mechanism of Action:
- Ascorbic Acid:
- Enhances the bioavailability of iron by maintaining it in the ferrous (Fe²⁺) state, which is more soluble and readily absorbed.
- Facilitates the transport of iron to storage sites in tissues.
- Acts as a reducing agent, preventing iron oxidation (to the less absorbable Fe³⁺ state) and aiding its incorporation into red blood cells.
- Iron:
- Essential for hemoglobin synthesis, which is critical for oxygen transport in the blood.
- Serves as a cofactor for enzymes like cytochromes, involved in energy production (electron transport chain).
- Helps in the formation of myoglobin and various enzymatic processes.
- Ascorbic Acid:
Folic Acid (Vitamin B9)
- Role in the Body:
- Necessary for nucleoprotein synthesis (DNA and RNA production).
- Supports normal erythropoiesis (red blood cell production), ensuring healthy oxygen transport.
- Prevents neural tube defects during early fetal development, making it vital for pregnant women.
- Metabolism:
- Folic acid is converted to its active form, tetrahydrofolic acid, in the liver and plasma via the enzyme dihydrofolate reductase.
- Involved in the synthesis of purines and thymidylate, critical for DNA replication.
Zinc
- Biological Importance:
- Acts as a cofactor for more than 100 enzymes, influencing various metabolic pathways.
- Crucial for DNA synthesis, cell division, and protein synthesis.
- Supports a healthy immune system, helping the body fight infections.
- Plays a role in maintaining the sense of smell and taste.
- May assist in the proper functioning of insulin, improving glucose metabolism.
This combination of ferrous ascorbate, folic acid, and zinc offers a comprehensive solution for:
- Treating iron-deficiency anemia.
- Supporting pregnancy and fetal development.
- Enhancing immune and enzymatic functions through adequate zinc levels.
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✔️ Uses of Zif-A Tablet
Iron, Folic Acid, and Zinc deficiency, Dietary supplement, Pregnanc,y and lactation
✔️ Pharmacology
Ferrous Ascorbate (Iron + Vitamin C):
- Iron is essential for hemoglobin formation and oxygen transport in red blood cells.
- Ascorbic acid (Vitamin C) enhances iron absorption and maintains its bioavailability.
Folic Acid (Vitamin B9):
- Supports red blood cell production and nucleic acid synthesis.
- Prevents neural tube defects in pregnancy.
Zinc:
- Plays a role in over 100 enzymatic processes, DNA synthesis, immune function, and insulin regulation.
✔️ Overdose Effects of Zif-A Tablet
Symptoms:
- Abdominal pain, nausea, vomiting, diarrhea, hypotension, seizures, and coma.
Action: Seek immediate medical attention in case of overdose.
✔️ Side Effects of Zif-A Tablet
- Common:
- Gastrointestinal discomfort: abdominal pain, nausea, vomiting, constipation, diarrhea, heartburn.
- Rare/Serious:
- Allergic reactions (rash, itching, swelling).
✔️ Dosage & Administration of Zif-A Tablet
Adults:
- 1–2 capsules/tablets daily, preferably on an empty stomach for better absorption. If GI irritation occurs, take it with or after meals.
Children (Over 1 Year):
- 1 capsule daily.
Elderly:
- 1 capsule daily or as prescribed by a physician.
✔️ Drug Interactions
- Tetracyclines and Antacids: May reduce iron absorption.
- Chloramphenicol: This may delay the response to iron therapy.
- Levodopa, Methyldopa, Penicillamine: Absorption may be reduced when taken together.
- Quinolones and Tetracyclines: Reduced efficacy due to impaired absorption of both drugs.
Recommendation: Avoid taking these medications within 2 hours of this supplement.
✔️ Contraindications:
- Hypersensitivity to any ingredients.
- Folic acid is contraindicated in untreated cobalamin (Vitamin B12) deficiency, as it may mask symptoms of pernicious anemia.
- Hemolytic anemia or other conditions with increased iron content in the body.
✔️ Pregnancy & Lactation
- Safe during the second and third trimesters of pregnancy.
- Avoid during the first trimester unless there is confirmed evidence of iron deficiency.
- Zinc supplementation is especially recommended during pregnancy and breastfeeding.
✔️ Key Advantages of the Ferrous Ascorbate Complex
- Improved Iron Utilization:
- Unlike other iron salts, ferrous ascorbate ensures high bioavailability of iron without dissociating in the GI tract, thus reducing side effects like nausea or constipation.
- Resistance to Food Inhibitors:
- Unlike ferrous sulfate, this complex is not significantly affected by phytates or tannins in the diet, allowing consistent absorption even with food.
- Direct Impact on Erythropoiesis:
- Ascorbic acid not only aids iron absorption but also has a direct effect on red blood cell production.
✔️ Precautions & Warnings
- Use cautiously in conditions such as:
- Iron Overload Disorders (e.g., hemochromatosis, hemolytic anemia, red cell aplasia).
- Renal Failure, where zinc accumulation risk exists.
- Failure to respond to treatment may indicate another cause of anemia and should be investigated.
- Avoid concurrent use with tetracyclines, antacids, or other medications that may interact with iron absorption.
✔️ Storage:
- Store below 30°C, away from light and moisture.
- Keep out of reach of children.
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